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Pancreatic Islet Cell Tumor
Condition Overview: Pancreatic-islet cell tumors appear in one of two forms. They may be nonfunctioning or functioning tumors. Nonfunctioning tumors may cause obstruction in the shortest part of the small intestine (duodenum) or in the biliary tract, which connects the liver to the duodenum and includes the gall bladder. These nonfunctioning tumors may erode and bleed into the stomach and/or the intestines, or they may cause an abdominal mass.Functioning tumors secrete excessive amounts of hormones, which may lead to various syndromes including low blood sugar (hypoglycemia), multiple bleeding ulcers (Zollinger-Ellison Syndrome), pancreatic cholera (Verner-Morrison Syndrome), carcinoid syndrome or diabetes. Islet cells are small, isolated masses of cells that make up the Islet of Langerhans in the pancreas. When functioning normally, they secrete the protein hormones insulin and glucagon. Tumors composed of irregular islet cells may occur alone or in a group of many tumors. Approximately 90% of islet-cell tumors are noncancerous (benign). They usually range in size from 0.5 to 2 cm in diameter. . |
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