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Opsoclonus-Myoclonus Syndrome
Condition Overview: Opsoclonus-myoclonus syndrome is a rare neurological disorder that usually affects infants and young children. It is characterized by the sudden onset of brief, repeated, shock-like spasms of muscles within the arms, legs, or entire body (myoclonus), an impaired ability to control voluntary movements (ataxia), and continual, involuntary, rapid eye movements in both horizontal and vertical directions (opsoclonus).In approximately 50 percent of affected individuals, a malignant tumor, usually a tumor of embryonic nerve cells (neuroblastoma), is responsible for the symptoms associated with opsoclonus myoclonus. In most other cases, the disorder may be due to a viral infection such as Coxsackievirus B3, poliovirus, or St. Louis encephalitis virus. Rarely, it may result from other underlying causes such as a tumor within the skull (intracranial tumors) or hydrocephalus, a condition in which inhibition of the normal flow of cerebrospinal fluid (CSF) and abnormal widening (dilatation) of the cerebral spaces of the brain (ventricles) causes accumulation of CSF in the skull and potentially increased pressure on brain tissue. |
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