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Muscular Dystrophy, Limb Girdle
Condition Overview: Limb-Girdle Muscular Dystrophy is a group of inherited, progressive disorders that are characterized by weakness and wasting (atrophy) of muscles of the hip and shoulder areas. Several different forms of the disorder have been identified that are caused by abnormal changes (mutations) of certain genes. Of these disease subtypes, at least eight have autosomal recessive inheritance and at least three are transmitted as an autosomal dominant trait. In most individuals with Limb-Girdle Muscular Dystrophy, associated symptoms and findings become apparent during childhood. However, less commonly, symptom onset may begin during adolescence or adulthood. Muscle weakness may spread from the lower limbs to the upper limbs or vice versa. Although the disorder typically progresses slowly, some affected individuals experience rapid disease progression. |
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