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Hemoglobinuria, Paroxysmal Cold
Condition Overview: Paroxysmal cold hemoglobinuria is a very rare autoimmune hemolytic disorder characterized by the premature destruction of healthy red blood cells minutes to hours after exposure to cold. Autoimmune diseases occur when the body's natural defenses against invading organisms (e.g., lymphocytes, antibodies) destroy healthy tissue for unknown reasons. Normally, red blood cells have a life span of approximately 120 days before they are removed by the spleen. In an individual affected with paroxysmal cold hemoglobinuria, the red blood cells are destroyed prematurely and suddenly (paroxysmally) upon exposure to temperatures of 10 to 15 degrees Centigrade and below.. |
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