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Astrocytoma
Condition Overview: An astrocytoma is a tumor that arises from the star-shaped cells (astrocytes) that form the supportive tissue of the brain. The World Health Organization (WHO) classifies astrocytomas into four grades depending on how fast they are growing and the likelihood that they will spread (infiltrate) to nearby brain tissue. Noninfiltrating astrocytomas usually grow more slowly than the infiltrating forms.Grade I astrocytoma is usually a noninfiltrating tumor. The most common type of grade I astrocytoma is pilocytic astrocytoma which is also known as juvenile pilocytic astrocytoma or JPA. This tumor grows slowly but can become very large. Pilocytic astrocytoma occurs most often in the cerebellum, cerebrum, optic nerve pathway and brainstem. This tumor occurs most often in children and teens and accounts for 2% of all brain tumors. Grade II astrocytoma is also called low-grade astrocytoma or diffuse astrocytoma and is usually an infiltrating tumor. This tumor grows relatively slowly and usually does not have well-defined borders. It occurs most often in adults between the ages of 20 and 60. Grade III astrocytoma is also called anaplastic (malignant) astrocytoma because this tumor grows into surrounding tissue and grows more quickly than a grade II astrocytoma. Anaplastic astrocytoma occurs most often in adults between the ages of 30 and 60, is more common in men and accounts for 4% of all brain tumors. Grade IV astrocytoma is also called glioblastoma multiforme or GBM and is the most invasive type of nervous system tumor. GBM is usually composed of a mix of cell types in addition to astrocytes. This tumor occurs most often in adults between the ages of 50 and 80, is more common in men, and accounts for 23% of all primary brain tumors. (For more information on this condition, choose "glioblastoma" as your search term in the Rare Disease Database”.) |
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