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Addison's Disease
Condition Overview: Addison's disease is a rare disorder characterized by chronic, usually progressive, inadequate production of the steroid hormones cortisol and aldosterone by the outer layer of cells of the adrenal glands (adrenal cortex). Classical Addison’s disease is a consequence of the loss of both of these hormones. Cortisol affects carbohydrate metabolism connective tissue development and the amount of water in the body. Aldosterone affects the sodium and potassium ion equilibrium (electrolyte imbalance) in the body, as well as water levels and, therefore, blood pressure and blood volume. Increased excretion of water and low blood pressure (hypotension) can lead to extremely low concentrations of water in the body (dehydration). Major symptoms of Addison's disease include fatigue, gastrointestinal discomfort, and changes in skin color (pigmentation).. |
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